Lignans and related compounds
Apexbio Technology LLC Podophyllotoxin 518-28-5 20mg
Podophyllotoxin (CAS 518-28-5) is a naturally occurring lignan that acts as a microtubule assembly inhibitor by binding to tubulin thereby disrupting mitotic spindle formation and inhibiting cell division This mechanism underlies its antineoplastic activity making it a valuable tool in studies of cell cycle regulation cytoskeletal dynamics and anticancer drug development Podophyllotoxin is widely used in biomedical research to investigate mechanisms of cytotoxicity and to screen for compounds targeting mitotic pathways The compound is supplied as 100 mg in a glass bottle or 50 mg in a poly bottle
Chemscene ChemScene | 9-Bromo-10-phenylanthracene | 25G | CS-W011944 | 0.98 | 23674-20-6| MFCD00230983 | 333.23
ChemScene | 9-Bromo-10-phenylanthracene | 25G | CS-W011944 | 0.98 | 23674-20-6| MFCD00230983 | 333.23
Medchemexpress LLC N-demethyl ivabradine-d6 hydrochloride | 98.0% | 497.06 g/mol | C26H29D6ClN2O5 | 5 MG
N-Demethyl Ivabradine-d6 hydrochloride is the deuterium-labeled N-demethyl metabolite of ivabradine supplied as the hydrochloride salt. It is provided as a solid powder intended for use as an analytical standard or tracer in quantitative NMR, GC-MS, or LC-MS applications.
- Deuterium-labeled (d6) analogue for use as an internal standard.
- High purity (98.0%).
- Provided as a hydrochloride salt in solid powder form.
- Available in small analytical pack sizes suitable for assay development.
- Storage stability: powder -20°C (3 years) or 4°C (2 years).
- Suitable as a tracer and internal standard for quantitative analysis by NMR, GC-MS, and LC-MS.
Apexbio Technology LLC Etoposide 33419-42-0 10mM (in 1mL DMSO)
Etoposide (VP-16) is a topoisomerase II inhibitor widely used in biomedical research to study mechanisms of DNA damage and cancer therapy It forms a stabilized complex with DNA and topoisomerase II preventing the enzyme-mediated religation of cleaved DNA strands Resulting DNA double-strand breaks lead to apoptosis particularly in rapidly dividing cancer cells Reported IC50 values vary across cell lines such as 59 2 M for topoisomerase II inhibition 30 16 M in HepG2 and 0 051 M for MOLT-3 indicating differential cytotoxic responses to etoposide in various cancer cell models
Selleck Chemical LLC O-Demethyl-Gefitinib-E0833-5MG
O-Desmethyl gefitinib a major active metabolite of gefitinib is a potent EGFR (ErbB1/HER1) inhibitor inhibits subcellular EGFR tyrosine kinase through a mechanism similar to that of gefitinib with IC50 values of 36 and 22 nM respectively
Apexbio Technology LLC Etoposide, 33419-42-0, MFCD00869325, 100 mg
MF: C29H32O13, MW: 588.56, Solubility: 29.45mg/mL in DMSO. Etoposide (VP-16) is the first agent recognized as a topoisomerase II inhibitor of anticancer drug with IC50 of 59.2 uM.
Pfanstiehl Inc Podophyllotoxin (P-126) 10g pack API, active pharmaceutical ingredient CAS: 518-28-5
Podophyllotoxin (P-126) 10g pack API, active pharmaceutical ingredient CAS: 518-28-5
